Facts about HDL cholesterol

HDL cholesterol is generally protective against heart disease, while LDL cholesterol actually increased the risk of high blood pressure, heart disease and stroke as well. HDL-cholesterol foods should be added to our diets. While the rest of your cholesterol numbers are good, works of HDL cholesterol to rid your body of LDL (bad) cholesterol. HDL cholesterol, alcohol is not to reduce? Bad? In addition, if you drink too much alcohol, this will lead to high blood pressure, which increases. Scientists continue to explore other drugs to increase your HDL level in the blood.

Torcetrapib: Although this drug significantly increases the level of HDL in the blood and decreases LDL or bad cholesterol, a recent study showed that use of torcetrapib is associated with increased mortality. The pharmaceutical company Pfizer was forced to discontinue the study, losing approximately $ 800 million invested in research and development of the drug. Maybe in a future similar drugs that are found not having the same impact on mortality.

HDL-Milano: For approximately 25 years ago a group of researchers in the University of Milan found Mr. Valerio Dagnoli. Valerio, a resident of a village in northern Italy called Limone sul Garda, is one of 40 people who have a mutation in the gene responsible for the synthesis of HDL. The resulting protein called Apolipoprotein A-? Milano is a variant of HDL apparently gives its carriers an impressive cardiovascular protection.

Protein A-? carries more effectively Milano excess cholesterol in the body helping a greater percentage of it is removed. May also be that this protein plays an antagonistic role in the development of atherosclerosis through anti-inflammatory effects. The forty individuals who carry this mutation in their genetic code without coronary heart disease and have a history of longevity, despite having low levels of HDL.

Following this discovery some scientists have given the task of reproducing the protein A-? Milano in the laboratory with the aim of creating a new therapy for patients with low HDL levels and coronary disease. The positive results of animal studies have recently advanced research in humans. Several scientific journals have reported studies suggesting that the infusion of this protein in humans could cause a significant regression of cholesterol plaques in the arteries of the heart. Although promising, this treatment is not a viable in this and that before being adopted must have been studied in a significant number of people.

LOW HDLs

Cholesterol associated with HDLs or HDLs is a powerful predictor of coronary heart disease. In this version III is defined categorically with the low HLDS <40 mg / dL, an increase over the values allowed in earlier versions that were <35 mg / dL. In this guide, a low HDLs, the targets of the LDL-lowering therapy and are used as a risk factor for estimating the risk of coronary disease in the next 10 years.

The low HDLs have several causes, many of which are associated with insulin resistance, ie, elevated triglycerides, overweight and obesity, physical inactivity and type 2 diabetes. Other causes are associated with snuff abuse, carbohydrate intake was too high (> 60% of calories) and some drugs (eg, b-blockers, anabolic steroids, progestogens). Version III of this guide does not specify values for raising HDLs. Although many clinical studies suggest that the increase in HDLs reduce the risk, the evidence is insufficient to specify a target for treatment. In addition, there are no drugs available that selectively increase HDLs. Despite this, pay attention to the low HDLs and treatment should follow the following sequence:

– All people with low HDLs, the primary goal of treatment is the LDLs, it being necessary to follow the recommendations of this guide for achieving that objective.

– Secondly, once collected the appropriate LDL, should focus attention to weight reduction and increased physical activity (particularly if metabolic syndrome is present).

– When HDLs are associated with a lower high triglycerides (200-499 mg / dL), the second priority is to achieve appropriate levels of non-HDL cholesterol as mentioned earlier.

Finally, if triglycerides are <200 mg / dL (isolated low HDLs) can be considered the use of drugs that increase the HDLs (fibrates or nicotinic acid), however, treatment of low HDLs isolated reserves, for people at high risk of stroke or equivalent.

Related posts

Releated Post

Leave a Reply

Your email address will not be published. Required fields are marked *